ABSTRACT
OBJECTIVE: To investigate and analyze the use of TCM national essential medicines in our hospital, so as to provide reference for clinical rational use. METHODS: The variety number, consumption sum and constituent ratio, defined daily dose system(DDDs), defined daily cost(DDC)and drug use distribution in departments of TCM national essential medicines in our hospital were statistic analyzed during 2013-2015. RESULTS: The variety number of TCM national essential medicines were relatively stable in our hospital, but the consumption sum and proportion showed a downward trend year by year. The consumption sum and DDDs of essential medicines changed less during 3 years, and the drug with large sales amount were relatively fixed, which showed that the clinical selection of essential medicines were relatively centralized, and the category and DDDs continuity of essential medicines was fairly good. The concentration ratio of TCM essential drug use were lower in clinical departments, and the consumption sum ratio were lower in TCM department. CONCLUSION: We must pay more attention to the rational use of essential medicines, and formulate relevant policies and measures to encourage clinical use essential medicines preferentially.
ABSTRACT
OBJECTIVE: To analyze the features of high-risk drugs prescriptions for elderly outpatients in our hospital, so as to provide references for establishing the prescription comment method of high-risk drugs used by elderly outpatients and promote the rational drug use. METHODS: The number and amount of money of high-risk drugs prescriptions for elderly outpatients were counted, and the amount of high-risk drugs were sorted, so as to find out the features of high-risk drugs use in elderly outpatients and determine the prescription comment catalogue. According to "The hospital prescription comment management specification (Trial)", and combined with the use of high-risk drugs and physical characteristics of elderly patients, the prescription comment technical manual of high-risk drugs used by elderly outpatients was established, and the key drugs were commented for demonstration purpose. RESULTS: Elderly patientsoccupied a high proportion in our hospital, and the amount of money of single prescription was also high, which indicated that the elderly patients had more complex drug use. Through analysis of high-risk drugs prescriptions, the comment catalogue was established. And through empirical review of the prescriptions of key drugs, it was found that the proportion of unreasonable prescriptions was high, with variousproblems among different prescriptions. CONCLUSION: This study established the prescription comment technical manual of high-risk drugs used by elderly outpatients, which should become an important measure to prevent and reduce drug-induced diseases in elderly patients, and improve the effectiveness and safety of clinical medication.
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OBJECTIVE: To analyze the clinical use Chinese herbal pieces in Beijing hospital, so as to provide references for the clinical rational medication. METHODS: The clinical dose, medication frequency, herb number, herb efficacy distribution and poisonous herb usage the traditional Chinese medicine (TCM) prescriptions in Beijing hospital were investigated, andwere contrasted with those described in Pharmacopoeia, classicalprescription and proved prescription, so as to deeply study the laws dose-effect-poisonous-ness relationship for TCM. RESULTS: There were about 500 Chinese herbal pieces, 28 poisonous herbs and 50 000 prescriptions per year in our hospital. Statistics showed that the doses some Chinese herbal pieces included poisonous herbal pieces were beyond the Pharmacopoeia regulated doses; herb numbers in some prescriptions were much larger than classicalprescription and proved prescription; tonic and antipyretic medicines were mostly used in these prescriptions. CONCLUSION: The clinical use TCM decoction pieces in our hospital were basically rational. The efficacy distribution the Chineseherbal pieces were consist with the gerontology characteristic and disease spectrum our hospital. However, there were some problems, such as large herb numbers and overdose some Chinese herbal pieces included poisonous herbal piecesin these prescriptions, should be further researched and improved.
ABSTRACT
OBJECTIVE: To analyze the varieties, pharmaceutical utilization, adverse drug reaction(ADR) and majority problems in clinical use of poisonous traditional Chinese medicines in Beijing hospital, so as to provide references for their clinical rational use. METHODS: The varieties of Chinese patent medicines contain poisonous ingredients in Beijing hospital were surveyed, and their poisonous ingredients, drug categories, consumption sums, defined daily dose system(DDDs), adverse reactions and rational uses were analyzed. RESULTS: There were more than 300 Chinese patent medicines in Beijing hospital, in which 105 contained poisonous ingredients. Pharmaceutical utilization research indicated that most of the poisonous Chinese patent medicines with much higher consumption sums and DDDs were used for orthopedics and cardio-cerebrovascular diseases. In the statistics of ADR for 5 years in our hospital, 185 ADR reports of Chinese patent medicines were collected, among which poisonous Chinese patent medicines were involved in 49 ADR reports. CONCLUSION: The poisonous traditional Chinese medicines play important roles in clinical treatment, however, the adverse reaction rates of these medicines were much higher and may cause serious outcome. Therefore, their poisonous constituents and action mechanisms should be researched in depth constantly and the research should be linked with their clinical practices, so as to ensure the safe and rational use of poisonous traditional Chinese medicines.